Scientific Names: Bidens bipinnata L.
Common Names:Gui Zhen Cao, San Ye Gui Zhen Cao.
为菊科植物三叶鬼针草Bidens pilosa L.的全草。
化学成分: 鬼针草 含水杨酸、原儿茶酸、没食子酸及脂肪酸类化合物。
Catechol (CAS: 120-80-9), given in drinking water to rats, was the most effective of 5 phenols in enhancing [3H]thymidine incorporation [( 3H]dThd-l) into esophageal DNA. To test for esophageal cocarcinogenesis, groups of 30 male MRC-Wistar rats received 3 weekly ip injections of 25 mg methyl-n-amylnitrosamine [(MNAN) CAS: 13256-07-0]/kg. From the time of the first MNAN injection, each group also received catechol, tannic acid (CAS: 1401-55-4), dried leaves of Bidens pilosa L., or croton oil (CAS: 8001-28-3) (respectively, 2, 10, 50, and 2 g/kg semipurified diet), or were given 20 ip injections of 6 mg phorbol (CAS: 17673-25-5)/rat. The rats were killed after 20-45, 46-52, or 53-72 weeks (subgroups A, B, and C). In the group given MNAN alone, most esophageal papillomas developed during the first 45 weeks. Both catechol and B. pilosa significantly increased the esophageal papilloma multiplicity (No. of papillomas/rat) induced by MNAN, with a maximum tumor yield of 2.2 times that in the corresponding subgroup treated with MNAN alone. Papilloma multiplicity increased from subgroup A to subgroup C in the MNAN plus B. pilosa group but not in the MNAN plus catechol group. No tumors were induced by the test cocarcinogens given without MNAN. We concluded that a) an increased esophageal [3H]dThd-I indicates potential cocarcinogenicity and b) catechol and B. pilosa were weak esophageal cocarcinogens. These results support the view that catechol in cigarette smoke and B. pilosa as eaten in South Africa contribute to the etiology of human esophageal cancer. (source)
- Wang J, et al.,
[Inhibition of 5 compounds from Bidens bipinnata on leukemia cells in vitro.
Zhong Yao Cai. 1997 May; 20(5):247-9. Chinese.
- Chang JS, et al.,
Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb.
Am J Chin Med. 2001; 29(2):303-12.
- Alvarez L, et al., Bioactive polyacetylenes from Bidens pilosa.
Planta Med. 1996 Aug; 62(4):355-7.
- Mirvish SS, et al., Test of catechol, tannic acid, Bidens pilosa, croton oil, and phorbol for cocarcinogenesis of esophageal tumors induced in rats by methyl-n-amylnitrosamine. J Natl Cancer Inst. 1985 Jun; 74(6):1283-90.