General

Scientific Names: Moghania philippinensis (Merr. et Rolfe) Li

Common Names: Qian Jin Ba, Yi Tiao Gen, Chou Kong Zai, Kao Shu Wei, Tou Di Long, Niu Da Li, Qian Li Ma.

BOTANICAL:

来 源： 为豆科植物千斤拔植物 Moghania philippinensis (Merr. et Rolfe) Li 的根。

植物特征： 主根粗如人指，一枝直下，长达50cm，甚难拔取，故名。高30～50cm，枝条柔软，幼嫩 都及花序有褐色毛。小叶3枚，倒卵状楔形至椭圆状长方形，或阔披针形，先端钝或锐，长5～6cm，润约1cm。托叶及苞小，常存，托叶干膜质，披针形，共 长尖，长5～6cm。花小，偏于一方。松驰之总状花序，蝶形花冠。苞极小，线形；萼长约5mm，密生绒毛，齿披针形：花冠有喙。荚果圆球形，具2种子，有 毛。

生药材鉴定： 本品为鼠尾状长条，通常不分枝，长25～70厘米，上部直径1～2.5厘米。外面灰黄色至灰褐色，顶端有细小芦头，各部均散生横长皮孔和细皱纹，表皮较 薄，刮去表皮后现棕褐色内皮。质坚韧，不易折断，切断面皮部棕红，易剥离，其余部分黄白色，有车辐状纹。气微，味微甘、涩。以根条粗壮而长、色黄白者为 佳。

Pharmacology

Efficacy

In the course of our search for natural estrogenic compounds from medicinal plants, we found that the methanolic extract from the roots of Moghania philippinensis (Fabaceae) showed significant effects on the proliferation of MCF-7 cells (human breast cancer) and induction of beta-galactosidase activity in a yeast two-hybrid assay. Through estrogenic activity-guided fractionation, we isolated several active flavonoids including prenylated ones. The CHCl(3) fraction and its new constituent, 8-(1,1-dimethylallyl)genistein (9), appreciably increased the uterine weight in ovariectomized rats when administered orally for 14 consecutive days, in which compound 9 showed stronger estrogenic activity than genistein. Antiestrogenic activities were also examined based on the inhibition of MCF-7 cell proliferation and beta-galactosidase activity in the yeast two-hybrid assay, mediated by 17beta-estradiol. 5,7,3',4'-Tetrahydroxy-6,8-diprenylisoflavone (6) showed the strongest antiestrogenic activity. (source)

IN VITRO:

1. Ahn EM, et al., Estrogenic and antiestrogenic activities of the roots of Moghania philippinensis and their constituents. Biol Pharm Bull. 2004 Apr; 27(4): 548-53.
   
   
   
   
   
   

Safety