Scientific Names: Boswellia carterii Birdw.
Common Names: Ru Xiang Shu,
Er Xiang, Zhi Ru Xiang, Chao Ru Xaing, Cu Ru Xiang, Jiu Ru Xiang, Sheng Ru Xaing, Ming Ru Xiang.
卡氏乳香树 Boswellia carterii Birdwo(B．sacranuek．)
化学成分: 含树脂 60～70%，树胶27～35%，挥发油3～8%。树脂的主要成分为游离 a、B一乳香脂酸（a、B一Boswellicacid）33%，结合乳香脂酸1．5%，乳香树脂烃（Olibanore-sene） 33%。树胶为阿糖酸（Arabic acid）的钙盐和镁盐20%，西黄芪胶粘素（Bassorin）6%；此外，尚含苦味质0.5%。挥发油呈淡黄色，有芳香，含蒎烯（Pinene）、消旋一柠檬烯（Dipentene）及a、B一水芹烯（a、B一Phellandrene），其主要的芳香成分未明。及其衍生物和间甲基酚（o-cresol）,中性部分含α－、β－香树脂素（α－，β－amyrin）的衍生物如α－香树脂酮（α－amyrone,α－amyrinone）尚含绿花白千层醇（viridiflorol）、乳香萜烯（insensole）及氧化乳香萜烯（insensole oxide）。树胶主要含多聚糖，分离得多聚糖I（polysaccharide I）,水解得阿拉伯糖、半乳糖及糖醛酸（uronic acid）；多聚糖Ⅱ（polysaccharide Ⅱ）,水解得糖醛及半乳糖。挥发油中乙酸正辛酯（octyl acetate）占92.46％，乙酸龙脑酯约1.4％，榄香烯0.22％，并含β－水芹烯（β－phellandrene）等。
Boswellic acid acetate (BC-4), a compound isolated from the herb Boswellia carterii Birdw., can induce differentiation and apoptosis of leukemia cells. Based on cell morphology and NBT reduction, BC-4 induced monocytic differentiation of myeloid leukemia HL-60, U937 and ML-1 cells at a dose under 12.5 microg/ml (24.2 microM). BC-4 was a potent inducer, with 90% of the cells showing morphologic changes and 80-90% of the cells showing NBT reduction. Specific and non-specific esterase were also increased by BC-4. Based on benzidine staining assay, BC-4 failed to induce erythroid leukemia DS-19 and K562 cells differentiation. In contrast to its selective differentiation effect, BC-4 strongly inhibited growth of all cell lines tested. The growth inhibition effect was dose- and time-dependent. In HL-60 cells, 20 microg/ml (38.8 microM) of BC-4 decreased viable cell number by 60% at 24 h, whereas at 3 days there was virtually no viable cells. Morphologic and DNA fragmentation analysis proved that BC-4 induced cell apoptosis. The dual apoptotic and differentiation effects of BC-4 suggest that it may be a powerful agent in the treatment of leukemia. (source)
The induction of cell differentiation and growth inhibition of HL-60 cells by Bc-4, an active principle from Boswellia carterii, was studied in vitro and in vivo. The proliferation of HL-60 cells was found to be inhibited by Bc-4 at a concentration of 5-10 micrograms/ml. Under the action of Bc-4, the acid phosphatase and NBT reduction activities in HL-60 cells were increased, and phagocytosis of cells was also induced. All these activities were concentration dependent. The HL-60 cells were induced by Bc-4 to differentiate into more mature cells morphologically. The in vivo growth of HL-60 cells in mouse subrenal capsules (SRC) and in diffusion chambers inoculated into mice was inhibited by Bc-4 at a dose of 50 mg/kg. The morphology of HL-60 cells treated by Bc-4 in diffusion chambers exhibited characteristics of mature granulocytic cells. (source)
- Qi Z, et al.,
[Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive].
Hunan Yi Ke Da Xue Xue Bao. 1999; 24(1):23-5. Chinese.
- Jing Y, et al.,
Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines.
Leuk Res. 1999 Jan; 23(1):43-50.
- Jing YK, et al.,
[Combination induction of cell differentiation of HL-60 cells by daidzein (S86019) and BC-4 or Ara-C].
Yao Xue Xue Bao. 1993; 28(1):11-6. Chinese.
- Jing Y, et al.,
Growth inhibition and differentiation of promyelocytic cells (HL-60) induced by BC-4, an active principle from Boswellia carterii Birdw.
Chin Med Sci J. 1992 Mar; 7(1):12-5.
- Jing Y, et al., Growth inhibition and differentiation of promyelocytic cells (HL-60) induced by BC-4, an active principle from Boswellia carterii Birdw. Chin Med Sci J. 1992 Mar; 7(1):12-5.