Scientific Names: Adenophora stricta MIq.
Common Names: Sha Shen, Nan sha Shen,
San Ye Sha Shen, Shan Sha Shen, Long Xu Sha Shen.
为桔梗科植物杏叶沙参Adenophora stricta Miq．的根。
植物形态: 多年生草本，有白色乳汁。茎高50～100cm。茎生叶互生，狭卵形或矩圆状狭卵形，长3～9cm，宽1.5～4cm，边缘有不整齐锯齿。花序狭长；萼钟状，先端5裂，裂片披针形，有毛；花冠紫蓝色，宽钟形，长约1.8cm，5 浅裂，裂片三角形，外面被毛，雄蕊5。花丝基部扩大，有密柔毛；子房下位，3室。蒴果球形。花期8～9月，果期9～10月。
Adenophora triphylla (AT), an oriental medicinal plant, was extracted using water and several organic solvents and each fraction was assayed for its tumoricidal effects on human Jurkat T cells with 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT). The influence on induction of apoptosis and G1 arrest was also examined. The ethyl acetate fraction showed the most pronounced inhibitory effects on proliferation of Jurkat T cells. Apoptosis was induced in line with up-regulation of FasL, tyrosine phosphorylation and c-fos mRNA levels. Arrest in G1 of the cell cycle was observed in A2780 cells with a wild type p53 gene but not HT-29 cells with a mutant p53 gene. Modifying effects of AT on cell turnover and glutathione(GSH) levels in vivo were also investigated in the stomach of rats given 150 mg/kg of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by gavage and then fed a diet supplemented with 5% or 1% pulverized AT and 0.5% or 0.2% ethylacetate-extracted AT for 42 hours. The 5% AT and both of the ethylacetate fractions caused significant reduction in proliferating cell nuclear antigen (PCNA)-labeling in the glandular stomach epithelium as compared with the value for the MNNG alone group. In addition, the treatments significantly increased the gastric GSH levels. These results suggest that AT could be a chemopreventive agent against gastric cancer. (source)
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Induction of apoptosis and inhibition of telomerase activity by aqueous extract from Platycodon grandiflorum in human lung carcinoma cells.
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Antioxidant and anticancer activities of organic extracts from Platycodon grandiflorum A. De Candolle roots.
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Suppressive effects of Adenophora triphylla extracts on in vitro tumor cell growth and in vivo gastric epithelial proliferation.
Anticancer Res. 2000 Sep-Oct; 20(5A):3227-31.