General

Scientific Names: Polygonum lapathifolium L.

Common Names: Suan Mo Ye Liao.

BOTANICAL:

来 源： 酸模叶蓼 Polygonum lapathifolium L．属蓼科一年生草本植物。

植物特征： 一年生草本，高30—200厘米。茎直立，上部分枝，粉红色，节部膨大。叶片宽被针形，大小变化很大，顶端渐尖或急尖，表面绿色，常有黑褐色新月形斑点，两面沿主脉及叶缘有伏生的粗硬毛；托叶鞘筒状，无毛，淡褐色。花序为数个花穗构成的圆锥花序；苞片膜质，边缘疏生短睫毛，花被粉红色或白色， 4深裂；雄蕊6；花柱2裂，向外弯曲。瘦果卵形，扁平，两面微凹，黑褐色，光亮。花期6—8月，果期7—10月。

Pharmacology

Efficacy

Four new phenylpropanoid esters of sucrose, lapathosides A (1), B (2), C (3), and D (4), were isolated from the aerial parts of Polygonum lapathifolium together with known esters, vanicoside B (5) and hydropiperoside (6). The structures of 1-4 were determined by spectral (1D and 2D NMR and MS) analysis. Lapathoside A (1) and vanicoside B (2) showed significant inhibitory effects on the Epstein-Barr virus early antigen activation by tumor-promoters. (source)

To search for cancer chemopreventive agents from natural resources, many phytochemicals have been screened using the in vitro synergistic assay indicated by the inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA). Two phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, were isolated from the aerial part of Polygonum lapathifolium as inhibitors on the EBV-EA induction. These compounds also exhibited significant anti-tumor-promoting effects on mouse two-stage skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA, as an initiator) and TPA as a promoter. Further, vanicoside B exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors initiated with an NO donor, NOR-1. (source)

IN VITRO:

1. Takasaki M, et al., New phenylpropanoid esters of sucrose from Polygonum lapathifolium. J Nat Prod. 2001 Oct; 64(10):1305-8.
2. Takasaki M, et al., Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium. Cancer Lett. 2001 Nov 28; 173(2):133-8.
   
   
   
   
   

Safety