General

Scientific Names: Michelia compressa .

Common Names: Wu Xin Shi, Tai Wan Han Xiao, Bian Yu Lan, Wu Zhi, Wu Ti.

BOTANICAL:

植物特征： 喬木，葉互生革質，披針形或長橢圓形，全緣而呈波狀，葉片不會隨季節之變化而大量掉落，而是老葉自然更新前，會轉變成紅色後再凋落；具有大型托葉包於幼芽處，外被赤褐色絹毛， 當托葉脫落後，於枝條上留有明顯的環形托葉痕，此種特徵是很容易辨認的；花為單獨腋生，花被片12枚呈白色，略帶淡淡的黃，花仍保有較原始的特徵，即雄蕊與心皮多數而離生，各呈螺旋狀排列，花瓣與花萼分別不甚清楚，合稱為「花被片」。果實穗狀著生，成熟時形成分離的蓇葖果，種子具有桃紅色的種皮。

Pharmacology

Efficacy

Liriodenine was isolated from the leaves of Michelia compressa. This study was designed to assess cell cycle arrest, the production of nitric oxide (NO) and p53 expression in liriodenine-treated human hepatoma cell lines, including wild-type p53 (Hep G2 and SK-Hep-1). As evidenced by flowcytometric studies, liriodenine induced cell cycle G(1) arrest and inhibited DNA synthesis in Hep G2 and SK-Hep-1 cell lines. The p53, iNOS expression and intracellular NO level were markedly increased in Hep G2 cells after liriodenine treatment. A NO inhibitor, carboxy-PTIO inhibited the p53 expression induced by liriodenine. In addition, liriodenine could not induce obvious cytotoxicity in normal human IMR-90 cell line. These results demonstrate that NO production and p53 expression are critical factors in liriodenine-induced growth inhibition in human wild-type p53 hepatoma cells. (source)

IN VITRO:

1. Hsieh TJ, et al., Liriodenine inhibits the proliferation of human hepatoma cell lines by blocking cell cycle progression and nitric oxide-mediated activation of p53 expression. Food Chem Toxicol, 2005 Jul; 43 (7): 1117-26.
   
   
   
   
   
   

Safety