General

Scientific Names: Lindera aggregata (Sims.) Kosterm.

Common Names: Wu Yao , Tian Tai Wu, Tai Wu, Ai Zhang, Xiang Gui Zhang, Gang Rong Zi, Ban Pi Zi.

BOTANICAL:

来 源： 为樟科植物乌药Lindera aggregata（Sims）Kosterm. 的干燥块根。

植物特征： 常绿灌木或小乔木，高可达5米。生于林缘、旷野、溪边灌丛中。根中部肥大，两端小，外皮 淡紫红色，内部白色。树皮灰绿色。小枝幼时密生棕褐色毛，老时平滑。叶互生，革质；叶片广椭圆形，长3～．6厘米，表面绿色有光泽，背面灰白色，幼时有 毛，主脉自基部三出。春季开花；雌雄异株，伞形花序腋生，总花梗不明显；花黄绿色，小花梗长约2毫米。核果球形，秋季成熟时黑色。

生药材鉴定： 本品多呈纺锤状，略弯曲，有的中部收缩成连珠状，长6～15cm，直径1～3cm；1表面黄棕色或黄褐色，有纵皱纹及稀疏的细根痕；质坚硬。切片厚0.2～2mm，切面黄白色或淡黄棕色，射线放射状，可见年轮环纹，中心颜色较深。气香，味微苦、辛，有清凉感。

Pharmacology

化学成分: 根含多种倍半萜类成份香樟烯(lindestrene)、香樟内酯(lindestrenolide)、羟基香樟内酯、乌药醇(linderenol)、乌药醚(linderoxide)、异乌药醚(isolinderoxide)、乌药酮(linderenone)。

Efficacy

IN VITRO:

1. Oh HM, et al., Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino. Bioorg Med Chem. 2005 Nov 15; 13(22):6182-7. Epub 2005 Aug 1.
2. Wang GL, et al., [Investigation on the molecular mechanisms of anti-hepatocarcinoma herbs of traditional Chinese medicine by cell cycle microarray]. Zhongguo Zhong Yao Za Zhi. 2005 Jan; 30(1):50-4. Chinese.
3. Li YM, et al., Extracts from the roots of Lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumor-bearing mice. Am J Chin Med. 2003; 31(6):857-69.
4. Yamashita M, et al., First total synthesis of (+/-)-Linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells. J Org Chem. 2003 Feb 21; 68(4):1216-24.
5. Tsia IL, et al., Cytotoxic butanolides and secobutanolides from the stem wood of Formosan Lindera communis. Planta Med. 2002 Feb; 68(2):142-5.
6. Tsia IL, et al., Cytotoxic butanolides from the stem bark of Formosan Lindera communis. Planta Med. 2001 Dec; 67(9):865-7.
7. Yamashita M, et al., The first total synthesis of (+/-)-linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells. Org Lett. 2001 May 3; 3(9):1359-62.
8. Huang RL, et al., Anti-tumor effects of d-dicentrine from the root of Lindera megaphylla. Planta Med. 1998 Apr; 64(3):212-5.
9. Mimaki Y, et al., A novel hexahydrodibenzofuran derivative with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells from Lindera umbellata bark. Chem Pharm Bull (Tokyo). 1995 May; 43(5):893-5.

IN VIVO:

1. Li YM, et al., Extracts from the roots of Lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumor-bearing mice. Am J Chin Med. 2003; 31(6):857-69.

Safety

用药忌宜： 气虚血亏，有内热者慎用。