General

Scientific Names: Artemisia vulgaris L.

Common Names: Ye Ai, Huo Ai, Wu Yue Ai.

 

BOTANICAL:

来 源: 本品为菊科植物野艾 Artemisia vulgaris L. 干燥的叶片。

植物特征: 高45-100厘米。中部叶1-2回羽状分裂,裂片椭圆形、披针形至线形,全缘或有锯齿,叶上面无腺点,近秃净,下面被白色丝状毛;上部叶近乎无柄,裂片狭窄如线。花期9-10月。

生药材鉴定: 干燥的叶片,多皱缩破碎,有短柄。叶片略呈羽状分裂,裂片边缘有不规则的粗锯齿。上面灰绿色,生有软毛,下面密生灰白色绒毛。质柔软,气清香,味微苦辛。以下面灰白色、绒毛多、香气浓郁者为佳。

 

 

 

Pharmacology

化学成分: 野艾的石油醚抽提取物中含侧柏酮、豆甾醇、β-谷甾醇、α-香树脂醇(α-Amyrin)及其乙酸酮、α-及β烯、羊齿烯醇(Fernenol)。又含多炔化合物去氢母菊酯(Dehydromatricaria ester)和十四碳-8,10,12-三炔-6烯-3-酮等。野艾所含挥发油的成分以1,8-桉叶素(Cineole)为主,其余为α-及β蒎烯、侧柏酮等。叶尚含廿四醇、β-谷甾醇、l-甲肌醇(l-Quebrachitol)和l-肌醇(l-Inositol )。根及茎含一种类似菊粉(Inulin)的多糖称蒿淀粉(Artemose)。根含多种炔化合物,其中有廿一碳-1,11,13-三烯-15,17,19-三炔,十四碳-8,10,12-三炔-6-烯-3-酮和十二碳-6,8,10-三炔-4-烯-3-酮。小枝还含有催产素(Oxytocin)样作用的物质。此外,野艾比其他植物含碘较多,也较易从土壤中吸收钡。

  1. Stavri M, et al., Bioactive constituents of Artemisia monosperma. Phytochemistry. 2005 Jan; 66(2):233-9.
  2. Kim DH, et al., Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. Biochem Pharmacol. 2004 Sep 15; 68(6):1081-7.

 

 

Efficacy

Extracts of Artemisia asiatica Nakai (Asteraceae) possess anti-inflammatory and antioxidative activities. Eupatilin (5,7-dihydroxy-3',4', 6-trimethoxyflavone), one of the pharmacologically active ingredients derived from A. asiatica was shown to induce apoptosis in human promyelocytic leukemia (HL-60) cells. In the present study, we examined the ability of eupatilin to induce apoptosis in human gastric cancer (AGS) cells. Eupatilin induced the apoptosis of AGS cells as revealed by a decrease in the ratio of pro-apoptotic Bax and anti-apoptotic Bcl-2, as well as the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP).The pro-apoptotic effects of eupatilin were further verified by its perturbation of the mitochondrial transmembrane potential (DeltaPsim). In addition, eupatilin treatment led to an elevated expression of p53 and p21. Eupatilin inhibited the activation of ERK1/2 and Akt, which are important components of cell-survival pathways. (source)

IN VITRO:

  1. Yance DR Jr, et al., Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther. 2006 Mar; 5(1):9-29.
  2. Kim MJ, et al., Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. J Environ Pathol Toxicol Oncol. 2005; 24(4):261-9.
  3. Berger TG, et al., Artesunate in the treatment of metastatic uveal melanoma--first experiences. Oncol Rep. 2005 Dec; 14(6):1599-603.
  4. Lee HG, et al., Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16. J Ethnopharmacol. 2005 Apr 26; 98(3):339-43.
  5. Wang GL, et al., [Investigation on the molecular mechanisms of anti-hepatocarcinoma herbs of traditional Chinese medicine by cell cycle microarray]. Zhongguo Zhong Yao Za Zhi. 2005 Jan; 30(1):50-4. Chinese.
  6. Stavri M, et al., Bioactive constituents of Artemisia monosperma. Phytochemistry. 2005 Jan; 66(2):233-9.
  7. Kim DH, et al., Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. Biochem Pharmacol. 2004 Sep 15; 68(6):1081-7.
  8. Li Y, et al., [Induction of apoptosis of cultured hepatocarcinoma cell by essential oil of Artemisia Annul L.]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 May; 35(3):337-9. Chinese.
  9. Rinner B, et al., Activity of novel plant extracts against medullary thyroid carcinoma cells. Anticancer Res. 2004 Mar-Apr; 24(2A):495-500.
  10. Chen HH, et al., [Inhibitory effects of artesunate on angiogenesis]. Yao Xue Xue Bao. 2004 Jan; 39(1):29-33. Chinese.
  11. Hong SH, et al., The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-kappaB activation in human hepatoma cell line and rat liver. Int J Mol Med. 2004 May; 13(5):717-20.
  12. Chen Y, et al., Effects of "moxibustion serum" on proliferation and phenotypes of tumor infiltrating lymphocytes. J Tradit Chin Med. 2003 Sep; 23(3):225-9.
  13. Wang Q, et al., [Experimental studies of antitumor effect of artesunate on liver cancer]. Zhongguo Zhong Yao Za Zhi. 2001 Oct; 26(10):707-8, 720. Chinese.
  14. Li Y, et al., Synthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group. Bioorg Med Chem. 2003 Mar 20; 11(6):977-84.
  15. Kim SH, et al., Synergistic induction of 1,25-dihydroxyvitamin D(3)- and all-trans-retinoic acid-induced differentiation of HL-60 leukemia cells by yomogin, a sesquiterpene lactone from Artemisia princeps. Planta Med. 2002 Oct; 68(10):886-90.
  16. Seo HJ, et al., Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. Int J Cancer. 2002 Aug 1; 100(4):456-62.
  17. Moneret- Vautrin DA, et al., Food allergy and IgE sensitization caused by spices: CICBAA data (based on 589 cases of food allergy). Allerg Immunol (Paris). 2002 Apr; 34(4):135-40. Review.
  18. Galal AM, et al., Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation. J Nat Prod. 2002 Feb; 65(2):184-8.
  19. Heo HJ, et al., Protective effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia asiatica against Abeta-induced oxidative stress in PC12 cells. Amyloid. 2001 Sep; 8(3):194-201.
  20. Seo HJ, et al., Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Mutat Res. 2001 Sep 20; 496(1-2):191-8.

IN VIVO:

  1. Lai H, et al., Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat. Cancer Lett. 2006 Jan 8; 231(1):43-8.
  2. Hong SH, et al., The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-kappaB activation in human hepatoma cell line and rat liver. Int J Mol Med. 2004 May; 13(5):717-20.
  3. Seo HJ, et al., Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. Int J Cancer. 2002 Aug 1; 100(4):456-62.

 

 

 

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